More than 100 million Americans struggle with chronic pain, according to one Institute of Medicine estimate, at an annual cost of as much as $635 billion in treatment and lost productivity. Further, the misuse of potent opioid painkillers, while increasing risk of addiction and abuse, can confuse the conversation around appropriate chronic pain management. This Forum brings together a panel of experts to discuss the causes, treatment and impact of chronic pain, while exploring the neuroscience behind the pain experience.