This Inaugural Conference ushers in a series of 4 annual meetings on Transdisciplinary Ancestral Genomics Research Insights (TAGRI) proposed to help diversify the Reference Human Genome, demystify and address medical paradoxes in underrepresented populations.  Leaders will gather in the fields of ancestral genomics & genetics, biology, engineering, chemistry, physics, medicine, epidemiology, evolutionary history, bioinformatics, nutrition, advocacy, policy and other relevant fields to impact and share the benefits of new genomic research across ecological niches, to underrepresented populations.