It has become increasingly clear that efforts to improve quality, lower costs, and enhance patient satisfaction cannot succeed without addressing socioeconomic status and nonmedical drivers of health-often called “social determinants of health”. However, the financing and oversight of holistic community initiatives is complicated, as they often involve a spectrum of municipal services, private entities, and all levels of government. This briefing will explore the economic, budgetary, and infrastructure issues that arise when creating outcome-oriented investments for social determinants.