“This is a series of six linked videos, interviews and articles featuring CNN Medical Editor Dr. Sanjay Gupta, who is also a practicing brain surgeon. It explores how new brain science is illuminating our understanding of how the mind works — and why sometimes it doesn’t work. Tools like the functional MRI machine are revealing circuits and structures in the brain that are important in depression and bipolar illness. It is research that may soon lead to far more effective treatments for these terrible diseases. 1. “Targeting Depression Deep Inside the Brain” An interview with Dr. Helen Mayberg who is using deep brain stimulation to treat severely depressed patients and is achieving remarkable results. This work has the potential to become a real breakthrough in treating the most intractable depression. 2. “Using Your Hands to Heal Your Head.” Two physicians, a hand surgeon and a psychiatrist, explain why working with your hands may relieve depression and anxiety. 3. “Writing a Roller Coaster – An Author’s Bipolar Illness is Revealed in Her Novel.” Juliann Garey wrote a novel while cycling through severe manic-depressive episodes. She discusses with Dr. Gupta the relationship between creativity and bipolar illness. 4. “Brain Images Reveal Clues About Depression” The functional MRI machine allows a researcher to test the relationship between a brain circuit and severe depression. 5. “The Reluctant Yogi” A grieving daughter uses yoga to wean herself from anti-depressants after the death of her father. 6. “How Can Happiness Be the Symptom of a Disease?” Hypomania, one phase of bipolar illness, is characterized by “euphoria, increased energy and a decreased need for sleep.” How can that be bad? Bipolar researcher Katherine Burdick explains, using Claire Danes’ portrayal of Carrie in Homeland as a well-known example.”