COVID-19 has, in many ways, been a different pandemic for men and women. Men are more likely to develop severe disease, while women more often endure long-haul symptoms. Cases of myocarditis have occurred primarily in young men after vaccination while women have greater stroke risk. COVID also triggers different stress-related mental health challenges. This webinar explores how biological sex shapes our immune response, how gender affects the way we experience stress—and how COVID focuses attention on the longstanding need to understand how sex and gender affect health and disease.