These so-called “longevity genes.”, are part of a class of proteins known as sirtuins, which help stem cells cope with stress. It is one of many areas of genetic research that scientists are studying to determine how and why some people can live to 100 or older in relatively good health.
Deeper dive
Scientists have long known of specific genes which affect healthy aging. While research may have future application for targeted disease treatment, other researchers point out that practical use is still a long way off. Focusing on things we can control now, such as improved chronic disease management, diet and exercise, is still the best way to promote healthy aging.
Researchers are now identifying genetic variants to gain insight into the physiology of healthy aging and to develop new therapies that can extend the human lifespan, by promoting more years of health. Through a highly detailed, large gene study of centenarians (100 and older), semi-supercentenarians (105+) supercentenarians (110 and over), researchers have identified particular genetic characteristics that seem to offer protection from age-related diseases. Gene variants improving DNA repair processes and for protecting against cardiovascular disease were particularly prominent in this cohort of very old people.