Tag Archives: prostate cancer

Ideas for covering Prostate Cancer Awareness Month

September is Prostate Cancer Awareness Month. Prostate cancer is the most common cancer among men in the United States, after skin cancer. It is also the second leading cause of death from cancer in men. Data from the National Cancer Institute show that prostate cancer occurs more often in African-American men than in white men and that African-American men with the disease are more likely to die from it than their white counterparts.

According to the American Cancer Society, one in seven men will be diagnosed with prostate cancer in his lifetime. Some 233,000 new cases are diagnosed annually; Nearly 3 million U.S. men currently live with prostate cancer And ACS estimates that 27,540 will die from the disease in 2015. However, most men with prostate cancer — about two-thirds — are older than 65, and do not die from the disease but from other causes.

Finding and treating prostate cancer before symptoms occur may not improve health or help men live longer; nor does every diagnosis warrant intervention. In 2012, the U.S. Preventive Services Task Force recommended against routine prostate-specific antigen (PSA)-based screening for prostate cancer, concluding that the expected risks of PSA screening are greater than the potential benefit. These risks include false positives that can lead to unnecessary treatment, with serious side effects for what is typically a very slow-growing disease. Continue reading

Senators push for research into prostate cancer

Barbara Boxer

Barbara Boxer

Two U.S. senators have proposed a bill to support research into prostate cancer, calling for “a national strategy to combat prostate cancer.”

Senators Barbara Boxer (D-Calif.) and Jeff Sessions (R-Ala.) have introduced the National Prostate Cancer Council Act, which would establish a body made up of federal agencies, patients, and medical experts. It would coordinate prostate cancer research and services across all federal agencies.

Jeff Sessions

Jeff Sessions

In a press release announcing the legislation, Sessions said, “Testing and early detection are the keys to combat this disease. When identified early, the survival rate for prostate cancer is very high. We need to ensure that we have the most advanced screening tools available and this legislation is a step in the right direction.”

The National Cancer Institute estimates there will be 233,000 new cases of prostate cancer and 29,480 deaths in the U.S. this year. Continue reading

ECRI reviews prostate cancer research

The ECRI Institute’s new review of recent research on the utility of off-label prescription of Finasteride in the prevention of prostate cancer (PDF) presents research and clinical guidelines. Its bibliography and research review may be useful for anyone considering a follow-up to Gina Kolata’s recent New York Times piece on cancer prevention. Finasteride blocks an enzyme that aids the proliferation of prostate cancer cells. It’s used to reduce the size of enlarged prostates and, under the name Propecia, to treat male pattern baldness.

A large trial on finasteride, known as the Prostate Cancer Prevention Trial (PCPT), was published in 2003. The 18,882 men (asymptomatic, with normal PSA levels, 55 years of age or older) enrolled in the trial were randomly assigned to receive either finasteride or placebo for 7 years. … The authors of the trial reported that finasteride reduced the incidence of prostate cancer from 24.4% to 18.4%; however, the incidence of high-grade prostate cancers was 25.6% higher in the finasteride group than the placebo group. The clinical significance of these findings is unclear and has been widely debated.

The impact of prophylactic finasteride on long-term mortality and quality of life was not reported by the PCPT. Two models forecasting the impact of finasteride on mortality in participants in the PCPT were published. Grover et al. predicted that for every 1,000 men treated with finasteride, a total of 20 life-years (0.02 years per individual) would be saved, and Lotan et al. predicted that men treated with finasteride would, on average, gain 1.7 months of life.

The ECRI release was prompted by Kolata’s piece in The New York Times which questions why drugs that have been proven to prevent cancer are not being taken while many potentially harmful (and useless) supplements are. Kolata mentioned the Finasteride case in addition to similar examples involving breast cancer prevention drugs.

According to its Web site, the nonprofit ECRI Institute “dedicates itself to bringing the discipline of applied scientific research to healthcare to discover which medical procedures, devices, drugs, and processes are best to enable improved patient care.” The acronym ECRI has been adopted as the organization’s full name, but used to stand for “Emergency Care Research Institute.”