Identification of cytolytic peptides as key virulence determinants for community-associated MRSA
Researchers have discovered a class of secreted staphylococcal peptides that have the ability to recruit, activate and subsequently lyse human neutrophils, thus eliminating the main cellular defense against S. aureus infection. These peptides are produced at high concentrations by standard CA-MRSA strains and contribute significantly to the strains' ability to cause disease in animal models of infection. The study reveals a previously uncharacterized set of S. aureus virulence factors that account at least in part for the enhanced virulence of CA-MRSA.
Identification of novel cytolytic peptides as key virulence determinants for community-associated MRSA
Published online: Nov. 11, 2007 | doi:10.1038/nm1656
Rong Wang, Kevin R Braughton, Dorothee Kretschmer, Thanh-Huy L Bach, Shu Y Queck, Min Li, Adam D Kennedy, David W Dorward, Seymour J Klebanoff, Andreas Peschel, Frank R DeLeo & Michael Otto